Primary Disease Name: Cholesterol
Primary Drug Name: Lescol
Chemical Drug Name: Fluvastatin
Lescol Information - What is Lescol?
Lescol is a prescription drug for lowering cholesterol. For people
with high cholesterol, Lescol (Fluvastatin), in combination with
diet, can reduce Low-density lipoprotein (LDL) cholesterol and triglycerides
levels significantly.
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Lescol Canada - Is Lescol from Canada Safe?
Canadian Interenet Pharmacies with the CIPA
seal are a part of the Canadian International Pharmacy Association
Canada and only ship drugs that are of the highest quality, and
as safe as in the United States.
CIPA Certified Canadian Pharmacies dispense only Health Canada approved
prescription drugs such as Lescol from Canada.
Health Canada is the equivalent to the US FDA and has standards
that match those of the FDA.
Prescription drugs from a Cipa Certified Canadian pharmacies are
just as good as those purchased in the United States and the generic
drugs, commonly purchased from online Canadian pharmacies, are of
the highest standard in the world. When purchasing your prescriptions
from an online Canadian Pharmacy you will notice that generic versions
of many popular brand names drugs are readily available.
Lescol from Canada and other Prescription drugs from Canada
points to note:
- All Drugs are approved by Health Canada
- Health Canada is Canada's equivilent to the FDA
- Canadian Generics are of the highest quality in the world
- Prescrition medications from Canada really are of the highest
quality in the world
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Lescol Side Effects
Lescol Side Effects: If you are prescribed Lescol
(Fluvastatin), be sure to alert your doctor as soon as possible
if you have any unexplained muscle pain, tenderness, or weakness.
Lescol is generally very well-tolerated. The side effects reported
most often are gas, stomach pain, indigestion, and constipation.
These side effects are usually mild and temporary. DO NOT USE Lescol
IF YOU ARE PREGNANT.
Other Possible Lescol Side Effects:
Headache, fatigue, stomach upset, stomach pain and diarrhea
may occur. If any of these effects persist or worsen, inform your
doctor. Notify your doctor if you develop: muscle aches or tenderness
(especially if fever is present), joint pain, chest pain, rapid
or pounding heart rate, weakness, nausea, yellowing eyes or skin,
dark urine, skin rash, vomiting. In the unlikely event you have
an allergic reaction to this drug, seek immediate medical attention.
Symptoms of an allergic reaction include: rash, itching, swelling,
dizziness, trouble breathing. If you notice other effects not listed
above, contact your doctor or pharmacist.
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Lescol Cholesterol Medication Mechanism of Action
Lescol works by blocking the enzyme HMG-Co A Reducatse. This enzyme
is required to make cholesterol in the liver. Therefore, less cholesterol
is made and the levels of cholesterol in the blood decrease. By
blocking this enzyme, Lescol also helps the liver to increase the
breakdown of the “bad” LDL cholesterol. Reduction of
cholesterol levels in the blood has been shown to reduce the risks
associated with heart disease such as heart attacks and strokes.
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Why is LDL Cholesterol "Bad"?
When too much LDL cholesterol circulates in the blood, it can slowly build up in the inner walls of the arteries that feed the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This condition is known as atherosclerosis. If a clot forms and blocks a narrowed artery, it can cause a heart attack or stroke. The levels of HDL cholesterol and LDL cholesterol in the blood are measured to evaluate the risk of having a heart attack. LDL cholesterol of less than 100 mg/dL (or total cholesterol levels of 4.7 millimoles per litre (mmol/L) is the optimal level. Less than 130 mg/dL (total cholesterol of 5.2 millimoles per litre (mmol/L) is near optimal for most people. A high LDL level (more than 160 mg/dL (6mmol/L) or 130 mg/dL (>5.2m/mol) or above if you have two or more risk factors for cardiovascular disease) reflects an increased risk of heart disease. That's why LDL cholesterol is often called "bad" cholesterol. Prescription drugs such as Lipitor (atorvastatin), Lescol (Fluvastatin), Pravachol (pravastatin), and Lescol (fluvastatin) have been shown to interfere in the synthesis of LDL by blocking an enzyme that helps produce cholesterol in the body.
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Diet and Benefits of Lescol
Dietary intake of cholesterol includes the contribution of animal
fats found in red meat, cheese, cream and whole cream milk and from
cooking oils. Oils that possess a high concentration of saturated
fats such as palmitic oils (palm & cottonseed oils), stearic
oils (lards & dairy fats), myristic and lauric oils (coconut
and palm kernel oils & dairy fats) are known to contribute more
towards the development of heart disease as compared to the lower
saturated fat based oils such as those containing oleic acids (olive,
safflower & sunflower oils) and lioleic acids (Seed oils; grape
seed oil & walnut oil). Health care professionals discourage
the use of cooking oils that possess higher levels of saturated
fats (as these assist oxidation of LDL and foam cell formation).
In addition, animal fats are rich in saturated fatty acids that
promote the accumulation of cholesterol. Rich animal fats have an
inverse effect on the production of LDL receptors in the liver,
so the individual with a diet that is high in animal fat is increasing
the risk of developing atherosclerosis. Drugs such as the statins
(Lipitor, Lescol, Lescol, Crestor, Pravachol, and Advicor) can help
to reduce the process of atherosclerosis by reducing LDL cholesterol.
LDL cholesterol is known as "the bad cholesterol." Excess
LDL builds up on your arteries (called a fatty streak) and may lead
to heart disease. The higher the level of LDL cholesterol, the higher
the risk for developing heart disease. Lowering elevated LDL cholesterol
can reduce the risk of heart attacks. Lescol can help to reduce
LDL cholesterol.
High-density lipoprotein, or HDL cholesterol, has earned the nickname
"the good cholesterol." That's because it is believed
to remove cholesterol from the blood. High levels of HDL in your
blood may help to reduce your risk of heart disease. A low level
can increase your risk of heart disease. Lescol can help to increase
HDL cholesterol.
Triglycerides are another type of fat in your bloodstream. Persons
with a high blood-triglyceride level have an increased risk of heart
disease. Lescol helps to reduce triglyceride levels.
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Why is HDL Cholesterol "Good"?
About one-third of blood cholesterol is carried by high-density lipoprotein (HDL). HDL cholesterol is known as the "good" cholesterol because a high level of it seems to protect against heart attack. (Low HDL cholesterol levels [less than 40 mg/dL] increase the risk for heart disease.) Medical experts think that HDL tends to carry cholesterol away from the arteries and back to the liver, where it's passed from the body. Some experts believe that HDL removes excess cholesterol from plaque in arteries, thus slowing the buildup.
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Lescol Dose and Supply
Lescol is available in two doses. Lescol comes as a 20mg capsule
and 40mg capsule. Lescol is usually recommended to be taken once
daily at bedtime. Lescol can be taken with or without regards to
meals.
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Lescol Storage
Lescol should be stored away from direct sunlight and kept in a
tightly closed container (vial) in order to prevent moisture from
affecting the tablet stability.
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How To Take Lescol
How to take Lescol ?
If your doctor has instructed you to take this once daily, take
it in the evening. You may take this medication with or without
meals. If your doctor has instructed you to take this more than
once daily, take it exactly as prescribed by your doctor. Long-acting
forms of Lescol must be swallowed whole. Do not crush or chew them.
Do not take this more often or increase the dose without your doctor's
approval. Your cholesterol level will not be lowered faster and
you may increase the risk of developing side effects.
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What Other Drugs will affect Lescol?
Tell your doctor of all the medications you may use (both prescription
and nonprescription), especially of: cyclosporine, gemfibrozil,
erythromycin, niacin, cimetidine, ranitidine, omeprazole, warfarin,
rifampin, cholestyramine, colestipol, itraconazole. Do not start
or stop any medicine without doctor or pharmacist approval.
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Additional Lescol Information
Lescol has shown to be a potent cholesterol reducing drug. However,
another agent recently released on the market by Astra-Zeneca, CRESTOR
(ROSUVASTATIN) is shown to have higher potency. It is also possible
to use a higher dose of the older, less expensive cholesterol reducing
agents to get a similar effect to that of Lescol or CRESTOR. These
drugs include LIPITOR (ATORVASTATIN), MEVACOR, ALTOCOR, or ADVICOR
(LOVASTATIN), PRAVACHOL (PRAVASTATIN), ZOCOR or Lescol XL (Fluvastatin).
Lescol is generally well tolerated and can be taken with many other
medicines. However, Lescol may interact with certain other cholesterol-lowering
drugs (e.g. Lopid or gemfibrozol).
Lescol may also interact with other medications including some
antibiotics, some antifungal medicines, and immunosuppressive medications.
Be sure to tell your doctor or pharmacist about all prescription
and nonprescription drugs you are taking.
Other Lipid lowering agents that are available and work differently
than the “statin” drugs include ZETIA (EZITIMIBE), LOPID
(GEMFIBROZOL), COLESTID (CHOLESTIPOL), TRICOR (FENOFIBRATE) and
QUESTRAN (CHOLESTYRAMINE).
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